Abstract

REVIEW ON BRAIN TARGETED DRUG DELIVERY SYSTEM (BTDDS)

Pawan Bhandari* and Pinky Bisht

ABSTRACT

Targeted drug delivery system is a method of delivering drug at a targeted site or particular area that increase the concentration of drug at the desired or particular site of action in the body and produces less side effects. The treatment of central nervous system (CNS) disease is challenging because the delivery of drug molecules to the brain is prevented by a variety of factors like physiological, biological, metabolic and some bio chemical barrier that collectively comprises the BBB (Blood Brain Barrier). The BBB acts effectively to protect the brain from circulating pathogens. Direct invasive methods can introduce therapeutics agents into the brain. Various strategies that have been used for delivering the drug across BBB. for drug delivery to brain include osmotic and chemical opening of BBB as well as the use of transport /carrier system. Many new approaches have been developed for example Magnetic drug targeting, chemical delivery Systems, Drug carrier systems (antibodies, liposomes or Nanoparticles). The most advantageous features of liposome are their ability to incorporate and deliver a large amount of drug. Nanoparticles exhibit an impressive attention in the field of targeted drug delivery system (Tdds) because of the possessing solid colloidal particles with a size range between 1- 1000nm. In this review we will discuss the methodologies for targeting the brain site and the mechanism.

Keywords: brain barrier, Drug delivery to brain, nanoparticles.