Abstract

ASSESSMENT OF INVITRO ANTI-ARTHRITIC ACTIVTIY OF ACHYRANTHES ASPERA LINN

K. Sujatha*, K. Kavitha, S. Manoharan

ABSTRACT

Achyranthes aspera Linn (Amaranthaceae) is described in Ayurveda for the treatment of painful inflammations, cardiac disorders and skin diseases. The present study was aimed to investigate the in-vitro antiarthritic activity of seed extract of Achyranthes aspera and to support its traditional use. The ethanolic extract of Achyranthes aspera was investigated for its anti- inflammatory activity by using protein inhibition assay method. The seven concentration of the extract and diclofenac sodium (10, 50,100, 200, 400,800, 1000 μg/ml) were used in this study as standard drug. The extract at the dose of 800 μg and 1000 μg /ml showed potent action on comparison with the standard diclofenac sodium. The results of the present study empirically indicate the Achyranthes aspera may be effective in treatment of rheumatoid arthritis and that is supports the common belief prevailing international medicines worldwide.

Keywords: Achyranthes aspera, Anti-arthritic activity, Diclofenac Sodium, Protein denaturation method.