Abstract

PREPARATION AND SCREENING OF NEW POLYHERBAL FORMULATIONS FOR THEIR WOUND HEALING ACTIVITY IN RATS

Ansar M. Patel*, Dr. R. V. Savadi 

ABSTRACT

The newly prepared Polyherbal formulations (Ointment, Gel and Liquid ) were evaluated for their wound healing activity in Excision and Incision wound models in rats. The wound-healing activity was assessed by the rate of wound contraction, period of epithelization and skin-breaking strength. In Excision wound model the Polyherbal Ointment treated group exhibit 99.78±0.11% reduction in wound area on 20th day when compared to standard Betadine Ointment and controls which was 98.55±0.44 % and 90.12±0.27% and faster rate of epithelization (16.55 ± 0.46). In the incision wound model, there was a significant increase in tensile strength (538.10± 1.52) was observed in ointment treated group. In all cases, there was a progressive decrease in wound area with time, indicating an efficacy of the formulations in healing the induced wounds. Our present study reveals that the new Polyherbal formulations posses potent wound healing activity, which could be a good choice of remedy for wound healing.

Keywords: Polyherbal Formulations, Betadine Ointment, Incision wound model, Excision wound model.