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Abstract

FORMULATION AND EVALUATION OF A NOVEL FLOATING IN SITU GEL SYSTEM FOR THE TREATMENT OF PEPTIC ULCER

Gunjan P. Malode*, Jatin J. Joita, Ashwini Y. Parbat, Lochana L. Malode, Jagdish V. Manwar, Ravindra L. Bakal

ABSTRACT

Oral-sustained release gel formulations with suitable rheological properties have been proposed as a means of improving the compliance of patients who have difficulties in swallowing oral dosage forms. The present investigation deals with the formulation and characterization of gellan gum based in situ gel of Lafutidine for the treatment of peptic ulcer. Lafutidine, a unique histamine H2-receptor antagonist and it is also used in the treatment of gastric ulcers, duodenal ulcers, and gastric mucosal lesions associated with acute gastritis and acute exacerbation of chronic gastritis. Gellan gum used as a polymer and calcium carbonate (CaCO3) was used as a cross- linking agent. In-situ forming polymeric formulations drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation in- situ to form a gel. The floating in situ gelling systems were prepared by dissolving varying concentrations of gellan gum in deionized water containing sodium citrate, to which varying concentrations of drug and calcium carbonate was added and dissolved by stirring. Prepared formulations were evaluated for viscosity, buoyancy lag time and buoyancy duration, drug content and in vitro drug release. The formulation variables like concentration of gellan gum and calcium carbonate significantly affected the viscosity, drug content, in vitro drug release from the prepared Lafutidine floating in situ gelling systems. It was observed that the prepared gel remained buoyant for 24 hr and slowly released Lafutidine over the period of 8 h. Thus, the floating in situ gel was formulated which achieved the controlled drug delivery in the stomach.

Keywords: Peptic Ulcer, Lafutidine, Priliminary test, Evaluation parameters.


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