Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS APRIL ISSUE PUBLISHED
  • APRIL 2021 Issue has been successfully launched on 1 April 2021.

Abstract

METHOD DEVELOPMENT AND VALIDAITON OF PEXIDARTINIB USING RP-HPLC

M. Vijaya Kumari* and Ch. Balasekhar Reddy

ABSTRACT

A simple, sensitive and rapid chromatographic method was developed and validated for the quantification of Pexidartinib using reverse phase HPLC. The chromatographic Separation was performed on a column X-Bridge C8 (150mmx4.6mm, 3.5 μ) with acetonitrile and 0.1% formic acid (70:30 v/v) as a mobile phase and flow rate was kept at 1 ml/min. Good sensitivity was found with UV detection at 225 nm. After method development the method was validated according to ICH guidelines. Chromatography was administered isocratically at ambient temperature and 5 min run time was maintained, then the retention time of Pexidartinib was found to be 2.271 min. The method was validated over the analytical linearity range from 4-60 μg/ml with r2 value 0.999. This method showed good reproducibility and recovery with % RSD in the desired range. The Limit of detection and Limit of quantification was found to be 0.04ug/ml and 0.4ug/ml. The proposed method can be successfully applied for the routine analysis of Pexidartinib in pharmaceutical dosage form.

Keywords: Development, validation, pexidartinib, HPLC.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More