Abstract

SUSTAIN RELEASE MATRIX TABLETS OF PERAMIVIR DRUG BY NATURAL POLYMER

Rajesh Meena, Sourabh Jain* and Karunakar Shukla

ABSTRACT

The present study includes the formulation and evaluation of sustained release matrix tablet of Antiviral drug. For this study Peramivir selected as model drug. For this study using natural polymer, to improve matrix performance and release characteristics, a water soluble hydrophilic additive like lactose Magnicium stearate was added. This study deals with the investigations carried out with the objective of developing oral sustained release formulations through matrix tablets for the widely used Antiviral drug Peramivir using natural gum as Taro gum and evaluation of their sustained release potential. Compatibility study of drug and polymer was conducted by employing FTIR Spectral. As the identical principal peaks were observed in all the cases, hence it shall be confirmed that interactions do not exist between the drug and polymer. The sustained release matrix tablet prepared by wet granulation technique using different proportions of natural polysaccharides. The pre compression characters of prepared granules for tablet formulation using different polysaccharide ratios were performed. The per compression parameters of prepared granules for tablet formulation using polysaccharide in different ratios. Sustained release tablet formulation prepared by using Taro gum which complies with official specifications. Further the release of drug from the tablet exhibited a sustained & controlled pattern over an extended time period.

Keywords: Antiviral drug; Peramivir; Controlled release; Taro gum.