Abstract

INVESTIGATION OF OBSTRUCTIVE AND RESTRICTIVE LUNG DISTRESS IN THE PATIENTS SUFFERING FROM SICKLE CELL DISEASE

Chandrakant More, M. Pharm, Hemakshi Chaudhari, M. Pharm, Harshal Wagh, M. Pharm and Savita Patil, M. Pharm Ph. D.*

ABSTRACT

Background of study: This Lung is one altogether important organs involved within the SCD. Two major complications of clinical lung involvement are acute chest syndrome and erythrocyte chronic lung disease. Material and Method: This was a multi-centric study was conducted at Shahada, Dist- Nandurbar. All test subjects were population with haemoglobin SS in a stable state at the time of study. The study variables included the FEV1, FVC, FEV1/FVC, FEF25-75%, PEFR, FET. Also blood transfusions in the past one to three months and the number of painful crises in the last one year, with physiologic pattern of respiration, age and gender. Results: In the study total no. of 140 patients enrolled, and divided into two groups; sickle cell disease suffers and control group. In this study we found obstructive and restrictive patterns in sickle cell patients. The restrictive pattern was found in 15 patients (28.5%) among the total no of participants and obstructive patterns (mild and moderate) found in 26 patients (37.09 %). In FVC, FEV1 and PEFR controls had higher in all age groups when compared with the HbSS population. The mean of FVC was (1.96±0.98 vs 3.01±3.44) P value <0.0001, FEV1 was (2.19±1.29 vs 3.01±0.86) P value <0.008, PEF was (5.63±2.03 vs 6.93±2.106) P value <0.0003 these all three parameters were statistically significant. Conclusion: The lung functions of SCD patients were statistically significantly reduced as compared to controls of similar age.

Keywords: Pulmonary function test, Sickle cell disease, Spirometry, Restrictive and Obstructive pattern, Forced Expiratory volume, Peak Expiratory Flow, Forced Vital Capacity.