Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS APRIL ISSUE PUBLISHED
  • APRIL 2021 Issue has been successfully launched on 1 April 2021.

Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC FOR DETERMINATION OF HYDROXYZINE PAMOATE BULK AND IN SUSPENSION FORM

T. Sudha*, M. Sathiya, C. Sathiyapriya, R. Sunitha, A. Vishali and J. Sujitha

ABSTRACT

The main objective was to develop and validate the UV-spectrophotometric method for the determination of Hydroxyzine pamoate bulk and in suspension formulation as per ICH guidelines. A simple, rapid, accurate and economical UV-spectrophotometric method has been developed for the estimation of Hydroxyzine pamoate bulk and in suspension formulation. The λmax of Hydroxyzine pamoate in methanol: buffer (50:50) was found to be 235 nm. The drug follows linearity in the concentration range 1–9 μg/ml with a correlation coefficient value of 0.999. The proposed method was applied to pharmaceutical formulation and percentage amount of drug estimated was 100.73%. It was found to be in good agreement with the label claim. The accuracy of the method was checked by recovery experiment performed at three different levels, i.e., 50%, 75% and 100%. The percentage recovery was found to be in the range from 99.2 to 101.6%. The percentage RSD value was found to be 1.3219. The low percentage RSD value indicated there was no interference due to excipients used in formulation. The proposed UV spectroscopy method can be effectively applied for the routine analysis of Hydroxyzine pamoate in the suspension formulation.

Keywords: Hydroxyzine pamoate, UV Spectrophotometric method, Validation, ICH guidelines, IR Spectrum.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More