Abstract

FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE PROLIPOSOMES OF VALSARTAN

N. Rajesh Kumar*, S. Leeba, S. Mounisha, M. Priyadharshini, M. Manikandan, M. Surendra Kumar

ABSTRACT

The aim of novel drug delivery system is to provide a therapeutic amount of drug to the appropriate site in the body to accomplish promptly and then maintain the desired drug concentration. The drugdelivery system should deliver drug at a rate control by the necessarily of the body over a specified term of treatment. The basic goal of novel drug delivery systems is to achieve a steady state blood or tissue level that is therapeutically effective and non toxic for an extended period of time. Sustained drug delivery involves the formulation of the drug into a suitable form, such as compressed tablet for oral administration. These dosage forms have been found to have serious limitations in terms of higher doses required lower effectiveness, toxicity & adverse effects. For over 20 years, researchers have appreciated the potential benefits of nanotechnology in providing vast improvements in drug delivery and drug targeting. Improving delivery techniques that minimize toxicity and improve efficacy offers great potential benefits to patients and opens up new markets for pharmaceutical and drug delivery companies.

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