Abstract

REVIEW ON NANOCOCHLEATES: A NOVEL CARRIER FOR DRUG TRANSFER

Mohammed Ishrath Begum*, Baddam Sunitha Reddy and Muhammad Fazal ul Haqq

ABSTRACT

Nanocochleates are novel drug delivery system which have ability to entrapment of desired drug molecule into the multilayered structure containing solid-lipid bilayer in the form of sheet rolled up in spiral shape. These are unique tailor-based system used for microencapsulation and delivery of therapeutics by entrapping them in supramolecular assemblies composed of negatively charged phospholipids and a divalent cation. Nanocochleates are widely used for oral and systemic delivery of wide variety of molecules including genes, vaccines, and antigens. Nanocochleate can encapsulate drugs which are hydrophobic, positively charged, negatively charged and poor orally bioavailable. Nanocochleates can be prepared by many methods & can be used to deliver many active agents for many applications. Nanocochleates is having very less limitations than that of other dosage forms & system & hence, it becomes widely applicable & more potential drug delivery system.

Keywords: Nanocochleates, Cochleate, Liposomes, Phospholipids.