Abstract

A STUDY ON THE IN VITRO ANTI HSV-1 ACTIVITY OF SECONDARY METABOLITES OF FUNGI ISOLATED FROM PONGAMIA PINNATA

Anand.D*, Anantha Padmanabhan.S, Saravanan.P, Rajarajan.S

ABSTRACT

Herpes simplex virus (HSV) causes a variety of life threatening diseases, since the chemotherapeutic agents available for HSV infections are either low in quality or limited in efficacy, there is a need to search new antiviral for HSV-1 infection. Fungal endophytes are good source of novel secondary metabolites having diverse structural groups and showing antibacterial, antifungal, anticancer, antiviral, antioxidant, insecticidal, antidiabetic and immunosuppressive activities. Therefore, the present study was undertaken to test the secondary metabolites of fungi from a potential medicinal plant of Pongamia pinnata against HSV-1. Six concentrations of fungal compounds were used for in vitro cytotoxicity assay on HEp-2 cell line which exhibits maximum toxic free concentration at 40μg. The toxic free concentrations of fungal compounds were assessed for antiHSV-1 activity. The fungal compounds showed inhibitory activity against HSV-1.

Keywords: Pongamia , Secondary metabolites, Antiviral, Colletotrichum, HSV-1.