Abstract

ANTICANCER ACTIVITY OF COMPOUNDS ISOLATED FROM MARINE ENDOPHYTIC FUNGUS ASPERGILLUS TERREUS

M. Suja*, S. Vasuki and N. Sajitha

ABSTRACT

The recent increase in cancer disease requires new drugs to conflict them. The sources have been found very rare in microorganisms, those from extreme habitats and from endophytes. In this present study the biological activity of the endophytic fungus associated with marine seaweed Codium decorticatum was assessed. The cytotoxic effect was evaluated using HepG2 cancer cell line. The seaweed endophytic fungi Aspergillus terreus producing compounds (F7 and F8) were evaluated for the anti cancer potentials. The results revealed that the compounds from the Aspergillus terreus showed better activity against cancer cell line. In the present study, the isolated compounds (F8 and F7) showed low Cytotoxicity on vero cell lines and also it inhibited the growth of the cancer cells.

Keywords: Aspergillus terreus, endophytic fungus, cancer cell.