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*S. Revathi, M.D. Dhana Raju

Department of Pharmaceutics, GIET School of Pharmacy, Rajahmundry, East Godavari Dt, Andhrapradesh 533 296.


Around 40 - 60% of potential drugs in the pharmaceutical market are lipophilic in nature due to the low aqueous solubility and low permeability and thereby facing problems in their formulation. Their rate-limiting step is the dissolution-rate of the drug. For BCS class II drugs which have the therapeutic delivery of lipophilic active moieties receive more attention due to this reason. One of the formulation systems that deal with poor solubility, slow dissolution rate is self-micro emulsifying drug delivery systems. The hypothesis behind dissolution rate enhancement with SEDDS is the spontaneous formation of the emulsion in the gastrointestinal tract which presents the drug in solubilized form and the small size of the formed droplet provides a large interfacial surface area for drug absorption. Due to its small globule size, the micro/nano-emulsifed drug can easily be absorbed through lymphatic pathways, thereby bypassing the hepatic first-pass effect. In practical use, the lipid formulations range from pure oils to blends which contain a strong proportion of hydrophilic surfactants or co-solvents. This review gives a complete summary of SEDDS which may be a promising approach to effectively overcome the problem of poorly soluble molecules.

Keywords: Poorly-soluble, surfactants, lipid-based, SEDDS, bioavailability.

[Full Text Article]

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