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Abstract

NEW STABILITY INDICATING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF DOLUTEGRAVIR AND RILPIVIRINE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Malleeswari Yerasani* and Nanda Kumar K. V.

ABSTRACT

A simple, Accurate, precise method was developed for the simultaneous estimation of the Dolutegravir and Rilpivirine in Tablet and pharmaceutical dosage form. Chromatogram was run through Std Altima C18 150 x 4.6 mm, 5. Mobile phase containing Buffer 0.01N Kh2po4: Acetonitrile taken in the ratio 70:30 was pumped through column at a flow rate of 1.0 ml/min. Buffer used in this method was 0.01N Kh2po4. Temperature was maintained at 30°C. Optimized wavelength selected was 260 nm. Retention time of Dolutegravir and Rilpivirine were found to be 2.351 min and 3.041 min. %RSD of the Dolutegravir and Rilpivirine were and found to be 0.2 and 0.5 respectively. %Recovery was obtained as 99.43% and 99.41% for Dolutegravir and Rilpivirine respectively. LOD, LOQ values obtained from regression equations of Dolutegravir and Rilpivirine were 0.18 , 0.54 and 0.27, 0.83 respectively. Regression equation of Dolutegravir is y = 27768x + 19554, and y = 39952x + 4847.7 of Rilpivirine. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.

Keywords: Dolutegravir, Rilpivirine, RP-HPLC.


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