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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

FORMULATION AND EVALUATION OF CLOTRIMAZOLE LOZENGES

Shravan Kumar Yamsani*, Pravalika Lakkam and Sofia Fathima

ABSTRACT

Clotrimazole is formulated as lozenges to provide slow release medicament for the management of oral thrush. Clotrimazole is an azole antifungal that works by preventing the growth of fungus. Many dosage forms like syrups, tablets available in market but still there is a need for new dosage form which acts effectively and locally for paediatrics and people with difficulty in swallowing. So the present investigation has been taken up design prepare and evaluate hard candy lozenges to meet the need of improved bioavailability. The benefits of these prepared lozenges showed increase in bioavailability, reduction in gastric irritation, bypassing of first metabolism and increase in onset of action. The lozenges are prepared using sucrose as base; liquid glucose is used for transparency and smoothness; Hydroxy propyl methyl cellulose K15M (HPMC K15M) are used as polymers. Sodium saccharine are used as artificial sweeteners. Sweeteners along with flavours are used to mask the bitter taste of drug. All the formulations prepared are subjected to various physicochemical parameters like weight variation, hardness, thickness, friability, content uniformity, and moisture content etc. the prepared formulations have a hardness of 8-11 kg/cm2, non-gritty and pleasant mouth feel. Some selected formulations are also tested for drug excipient interactions subjecting to Infrared Spectral analysis, in vitro release rate studies showed that the drug release for lozenges was maximum in formulation F6 (99.52±1.23%) after 25 minutes. The moulded lozenges can provide an attractive alternative formulation in allergic condition.

Keywords: Clotrimazole, antifungal, lozenges, saccharine, K15M, liquid glucose.


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