Abstract

PHYTOCHEMICAL EVALUATION AND ANXIOLYTIC ACTIVITY OF AEGLE MARMELOS LEAVES EXTRACTS IN MICE

Sonpreet Kaur*, Abhishek, Maninder Kaur, Ajeet Pal Singh and Amar Pal Singh

ABSTRACT

Anxiety is one of the most common mental disorders, characterized by changes in mood, behavior, somatic function, and cognition. Phobias are the most common with the highest rates for simple phobia and agoraphobia. Panic disorder (PD) and obsessive-compulsive disorder (OCD) are less frequent (2% lifetime prevalence), and there are discordant results for social phobia (SP) (2%-16%) and generalized anxiety disorder (GAD) (3%-30%).Benzodiazepines and SSRIs are most commonly employed drugs for the treatment of anxiety and provided various side effects. Drugs obtained from natural sources are known to cause fewer side effects compared to synthetic drugs despite of same ability to cure disease. Aegle marmelos is an ayurvedic medicinal tree belongs to family Rutaceae. It is commonly known as apple tree, stone apple tree found all over India. Aqueous and Ethanolic leaves extracts of Aegle marmelos used to evaluate Anti- Anxiety activity. These extracts administered orally in two different doses 150 mg/kg and 300 mg/kg as compare to dose of Standard drug (diazepam) 1 mg/kg. Plasma Corticosterone Level was also estimated by collected blood from tail vein after behavioral parameters. The results of our study demonstrated that the ethanolic and aqueous extracts of Aegle marmelos fruit have significant anxiolytic activity in LDM and OFT models of anxiety and also shown significant results in biochemical estimation.

Keywords: Aegle marmelos, Anti-Anxiety, Corticosterone levels, Light Dark Model (LDM) and Open Field Test (OFT).