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Abstract

FORMULATION AND EVALUATION OF BILAYERED TABLETS OF PARACETAMOL WITH COMBINATION OF METHOCARBAMOL

Vimal Kumar Iglasiya*, Mohit Khandelwal, Dr. Dilip Agrawal, Dr. Rakesh Goyal, Ashok Kumar Sharma and Shaneza Aman

ABSTRACT

The aim of present work was to develop a robust formulation of Bi-layer tablets of Paracetamol and methocarbamol using povidone k-30 as binder. The aim of this Bi-layer tablet formulation is to separate physically or chemically incompatible ingredients and also to produce prolonged action tablet. These drugs may be developed to reduce pain. The mechanism of methocarbamol is a skeletal muscle relaxant which acting centrally through inhibiting inter neuronal activity and blocking polysynaptic reflex pathway at spinal cord. Paracetamol is a pain relieving agent which inhibits the activity of Cyclooxygenase, an enzyme required for synthesis of prostaglandins. A total number of nine formulations have been taken to optimize and develop a stable formulation. Wet granulation process was used for the formulation of bi-layer tablet and the final film coated tablets were evaluated for the, thickness, weight variation, hardness, friability, disintegration time, dissolution study. Among the formulations of tablet, Formulation NO.8 (F8) was choosen as optimized formula due to its higher rate of dissolution and compiled all the other parameters with the official standards.

Keywords: Paracetamol and methocarbamol, Bi-layered tablets, Povidone K-30, Wetgranulation process.


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