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Nazim Ali*, Yogendra Pal and Shashi Bhooshan Tiwari


Objective: The aim of the present study is to evaluate the antiulcer activity of ethanolic extract of Momordica charantia in pylorus ligation gastric ulcer in rats. Method: Gastric ulcer was induced by pylorus ligation method. In pylorus ligation model, Rats of either sex were divided into four groups, group 1 received vehicle (distilled water 1ml/kg), group 2 (standard) received Ranitidine (10mg/kg) and group 3,4 were treated with ethanolic extract of 150mg/kg and 300mg/kg 10 days pretreatment. Rats were deprived of food, but not water, for 24 hours prior to the experiment. On 10th days, 1 hour after the respective treatments, pylorus ligation performed under diethyl ether anesthesia. Four hours later, animal were sacrificed by cervical dislocation and stomach was open along the curvature and ulcer was graded. Percentage of ulcer protection, ulcer index, free acidity, total acidity, and pH were observed and calculated. Result: The extract of Momordica charantia in pylorus ligation model. It decreased the ulcer index (0.80), and there was a decreases in total acid and free acid (p<0.001), and increases the pH value (p<0.001), increases the percentage of ulcer protection (65.66). Conclusion: Ethanolic extract of Momordica charantia was clearly shows a protective effect against total acid, free acid and ulcer index and also increase pH, and percentage of protection against ulcer in pylorus ligation model.

Keywords: Momordica charantia, pylorus ligation, Ranitidine, peptic ulcer, prostaglandin.

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