Photo Gallery



News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.



Arpita Choudhary*, Dr. Sailesh Narayan, Dr. Shailendra Bindaiya and Dr. Shailendra Lariya


The present study was performed to evaluate the ameliorative effect of celastrus paniculatus against CCl4 induced hepatotoxicity in rats. In the present study, Celastrus paniculatus was selected for hepatoprotective activity owing to its traditional use. The liver function is assessed by determining the activities of SGOT, SGPT, SALP, i.e. enzymes present in the cytoplasm. In case of hepatotoxicity, the enzymes move into the bloodstream and their amount confirms the liver damage extent. The plant material was extracted by continuous hot percolation Soxhlation and the percentage yield calculated by the following formula was found to be 2.41 % (by ethanol). Phytochemical screening of ehanolic extract of Celastrus paniculatus showed the presence of carbohydrate, alkaloid, protein, flavonoids, tannin and phenolic compound, saponin, triterpenoids and steroids and absence of glycoside. In case of acute oral toxicity study when animals were treated with 5, 50, 300, and 2000 mg/kg b.w. of dose for 72 hour there was no mortality and any behavioural changes, so the dose will be choosen as 200 mg/kg b.w. on the basis of LD50. Administration of ethanolic extract showed a substantial decrease in SGPT, SGOT, SALP level (p <0.05) at a dose of 200mg/kg. Similarly, treatment with hepatoprotective drug such as silymarin showed a significant decrease in SGPT, SGOT and SALP levels. Therefore, it was reported that Celastrus paniculatus extract treatment normalize few morphological features of the liver in rats with CCl4- induced hepatotoxicity.

Keywords: Ethanolic extract of Celastrus Paniculatus, Soxhlation, Hepatotoxicity, Silymarin, CCl4 induced hepatotoxicity.

[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More