Abstract

ACOUSTICAL STUDIES & MOLECULAR INTERACTIONS IN DIFFERENT SOLUTION OF LEVETIRACETAM DRUG AT 303K, 308K, 313K,

Chandani Sinha and *Kaushlendra Kumar

ABSTRACT

The molecular interaction behavior of antiepileptic drug Levetiracetam its molecular interaction was studied using ultrasonic technique at 6MHz frequency at three different concentrations 0.1 M, 0.01M, 0.001 M. Ultrasonic velocity, viscosity and density were measured at 303K, 308K, 313K. Different Interaction parameters like adiabatic compressibility, Intermolecular free length, Specific acoustic impedence, Rao’s constant, Wada’s constant, Apparent Molar compressibility, Relative Association, Relaxation time, Free volume etc have been calculated using the experimental values of density, viscosity, and ultrasonic velocities of aqueous solution of levetiracetam. Results are interpreted in terms of solute-solvent interactions. In these systems, the magnitude of the excess acoustical parameters values inferred the solute-solvent interactions in the system. This interaction may be due to rupture of hydrogen bonds via dissociation or dilution that occurs between the water molecules.

Keywords: Ultrasonic Velocity, Adiabatic compressibility, Apparent Molar, Relaxation time, compressibility, free volume.