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  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

DEVELOPMENT AND VALIDATION: RP-HPLC METHOD FOR ESTIMATION OF ASSAY OF NALBUPHINE HYDROCHLORIDE IN INJECTION FORM

Pavankumar Gangavarapu*

ABSTRACT

Nalbuphine is an analgesic antagonist. It is roughly weight-based to morphine when the parenteral administration of 'normal doses is applied in analgesic practices. Even reasonable anesthesia is evident when used as an 'equilibrium' anesthesia procedure, though its utility in this sense is constrained by a relative 'ceiling' effect in minimizing anesthesia requirements with nalbuphine. Like most analgesics’ agonists/antagonists, there is also an effect of 'ceiling' of nalbuphine-induced respiratory depression that does not appear readily. Chromatography is mainly used in chemical analytics, but mainly a separation method, with high-performance liquid chromatography (HPLC) being a highly flexible technique in that analytes are isolated by a column containing micrometer particles. Now the most widely used HPLC separation method is reverse-phase day chromatography. The explanations are basic, flexible and the scope of the reversed-phase approach because compounds of a varied polarity and molecular mass can be handled. Analytical and preparational applications in biochemical separation and purification were established both in reversed-phase chromatography. The reversed-phase chromatography of molecules with excellent recovery and resolution will distinguish them with some hydrophobic characteristics, such as proteins, peptides, and nuclear acids.

Keywords: Nalbuphine, Analgesic, HPLC, Placebo.


[Full Text Article]

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