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Abstract

DEVELOPMENT AND EVALUATION OF ORALLY DISINTEGRATING TABLETS OF FENOFIBRATE BY DIRECT COMPRESSION METHOD

L. Satyanarayana, K. Sushmitha*, K. Samatha, M. Sailaxmi and S. Mounika

ABSTRACT

One important drawback of solid dosage forms is the difficulty in swallowing or chewing in some patients, particularly pediatric and geriatric patients. Hence the main aim of the study is to formulate oral disintegrating tablets of Fenofibrate to achieve rapid dissolution, absorption and further improving the bioavailability of the drug. Dissolution test was carried out using USP rotating paddle method (apparatus 2). The 6.8 pH phosphate buffer was used as a dissolution medium (900ml) and was maintained at 37 °C. Samples of 5ml were withdrawn at predetermined intervals (5,10,20,25,30 and 45mints.) filtered and replaced with 5ml of fresh dissolution medium. The collected samples were suitably diluted with dissolution fluid, where ever necessary and were analyzed for the Fenofibrate at 246nm by using UV spectrophotometer. Oral disintegrating Tablets of Fenofibrate were developed with a view to enhance the patient compliance and provide a quick onset of action. Hence it is very conducive to prepare the oral disintegrating tablets ofFenofibrate.

Keywords: Fenofibrate, Ac-Di-Sol, PolyPlasdoneXl and Tulsion 339.


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