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Abstract

SLEEP ARCHITECTURE AND QEEG POWER SPECTRA IN ADOLESCENT SCHIZOPHRENIA PATIENT

Ashish Kumar and Sunil Pandey*

ABSTRACT

Objectives: Sleep abnormality persistence present in adult schizophrenia patients in adolescent schizophrenia sleep is sensitive parameter to evaluate pathogenesis behind illness. The present study aimed to compare polysomnography (PSG) data between adolescent schizophrenia patients and healthy controls. Methods: Both conventional sleep architectural and power spectral analyses were conducted. 10 patients, 10 first degree relative and 10 healthy subjects were enrolled with age and sex matched. A 2 nights’ sleep (firsthabituation and second-experimental) PSG data was collected. Computer assisted scoring supplemented by manual method using the Rechtschaffen and Kales criteria were used for sleep staging. 28 channels were used for the EEG recording. Spectral power across early NREM (Non-rapid-eye-movement), Slow Wave Sleep and REM was computed using the Welch's averaged periodogram method. Result: In adolescent schizophrenia patients have disturbed sleep pattern. There is significant difference in between TST (p>.001), SE (p>.01), TAT (P>.001), NREM2 duration (p>.001). Disturbed sleep pattern of early onset schizophrenia is correlated with clinical characteristics of patients positive correlation with duration of illness and TAT and NREM1 duration and negative correlation with duration of illness and NREM3 duration. Spectral power is lesser in patient group and Inter and intra hemispheric coherence is greater in patient group across various sleep stages and various frequency bands.

Keywords: Schizophrenia; adolescent; polysomnography; sleep architecture; power spectral analysis.


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