Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

AN ANALYTICAL APPROACH OF AZELNIDIPINE: A REVIEW

Drashti Mandale*, Rujuta Mistry and Dr. Nidhi Chauhan

ABSTRACT

Azelnidipine (AZEL) is chemically (±)-3-(1-diphenylmethylazetidin3-yl) 5-isopropy12-amino-1, 4-dihydro-6-methyl-4-(3-nitrophenyl) 3,5-pyridinedicarboxylate. It is a dihydropyridine (DHP) type of calcium channel blocker (CCB) used for the treatment of hypertension. AZEL has two enantiomers due to an asymmetric carbon at the 4-position of the DHP ring. The pharmacological action of AZEL resides in the (R)-enantiomer. This is in marked contrast to other CCBs in which the (S)-enantiomer is responsible for the biological activity. The peculiar three-dimensional structure of the active enantiomer of AZEL may be related to its unique pharmacological features that are not shared by other DHPs such as long lasting reduction in blood pressure, decreased heart rate and antiatherosclerotic effect. AZEL also shows diuretic effect by increasing urine volume and thus reduction in retention of ions. Some analytical methods for the quantitative determination of Azelnidipine in pharmaceutical formulations like UV, LCMS/MS, RP-HPLC, HPLC-MS/MS, UFLC, LC-ESI-MS

Keywords: Azelnidipine, hypertension, UV, LCMS/MS, RP-HPLC, HPLC-MS/MS, UFLC, LC-ESI-MS


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More