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Drashti Mandale*, Rujuta Mistry and Dr. Nidhi Chauhan


Azelnidipine (AZEL) is chemically (±)-3-(1-diphenylmethylazetidin3-yl) 5-isopropy12-amino-1, 4-dihydro-6-methyl-4-(3-nitrophenyl) 3,5-pyridinedicarboxylate. It is a dihydropyridine (DHP) type of calcium channel blocker (CCB) used for the treatment of hypertension. AZEL has two enantiomers due to an asymmetric carbon at the 4-position of the DHP ring. The pharmacological action of AZEL resides in the (R)-enantiomer. This is in marked contrast to other CCBs in which the (S)-enantiomer is responsible for the biological activity. The peculiar three-dimensional structure of the active enantiomer of AZEL may be related to its unique pharmacological features that are not shared by other DHPs such as long lasting reduction in blood pressure, decreased heart rate and antiatherosclerotic effect. AZEL also shows diuretic effect by increasing urine volume and thus reduction in retention of ions. Some analytical methods for the quantitative determination of Azelnidipine in pharmaceutical formulations like UV, LCMS/MS, RP-HPLC, HPLC-MS/MS, UFLC, LC-ESI-MS

Keywords: Azelnidipine, hypertension, UV, LCMS/MS, RP-HPLC, HPLC-MS/MS, UFLC, LC-ESI-MS

[Full Text Article]

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