Abstract

IMMEDIATE RELEASE DRUG DELIVERY SYSTEM: A REVIEW

Vishal G. Rathod, Vaishali Kadam, S. B. Jadhav, Md. Zamiruddin, V. B. Bharkad, Suprabha P. Biradar

ABSTRACT

The drugs administered by oral route are versatile, flexible in dosage strength, relatively stable, present lesser problem in formulation and packaging and are convenient to manufacturer, store, handle and use. Solid dosage forms provide best protection to drugs against temperature, light, oxygen and stress during transportation. As a drug entity nears the end of its patent life, it is common for pharmaceutical manufacturers to develop a given drug entity in a new and improved dosage form. Drug delivery systems (DDS) are a strategic tool for expanding markets/indications, extending product life cycles and generating opportunities. Oral administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and most importantly, patient compliance. Tablet is the most popular among all dosage forms existing today because of its convenience of self-administration, compactness and easy manufacturing, however in many cases immediate onset of action is required than conventional therapy. To overcome these drawbacks, immediate release pharmaceutical dosage form has emerged as alternative oral dosage forms. Immediate release solid oral dosage forms are classified as either having rapid or slow dissolution rates. Immediate release dosage forms are those for which ≥85% of labelled amount dissolves within 30 min. For immediate release tablets, the only barrier to drug release is simple disintegration or erosion stage, which is generally accomplished in less than one hour.Disintegrating agents are substances routinely included in tablet formulations and in some hard shell capsule formulations to promote moisture penetration and dispersion of the matrix of the dosage form in dissolution fluids.

Keywords: Immediate release tablet, superdisintegrants, polymers