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Abstract

EVALUATION OF ANTIULCER AND GASTRO-PROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF WHEATGRASS ON ETHANOL-INDUCED ALBINO WISTAR RATS

Mrs Sainu Susan Oommen, Dr. Hilda Fernandes and *Dr. Rajendra Holla

ABSTRACT

Peptic Ulcer (PU) is the main health risk with regards to morbidity in addition to mortality. Wheatgrass (WG) has the ability to stimulate metabolism, restore alkalinity of the blood, along with that due to its abundant alkaline minerals, the acidity in the blood can be lessened. Its therapeutic use can be justified by providing a scientific view with information on the qualitative in addition to quantitative compositions along with antioxidant property. The intention of the study is to examine the gastroprotective effects of Ethanolic shoot extract of wheatgrass (EWG) in ethanol-induced Gastric Mucosal (GM) ulceration in Albinos Wistar rats (WR). The EWG is assessed aimed at anti-ulcerogenic effects utilizing ethanol (ulcerogen). The experimentalgroup was given the extract at a dosage of 200-400 mg/kg bwt orally, whilst the control and reference groups were provided distilled water as well as omeprazole (20mg/kg, p.o), correspondingly. Phyto-Chemical (PC) studies exposed the saponins, tannins, vit.C, flavonoids, glycosides, alkaloids, in addition to resins presence. The outcomes illustrated that the extract considerably (p<0.05) lessened the Ulcer Indexes (UI) as of 9.16±1.76 to 2.19±0.42 in ethanol-induced ulceration. The extract as well considerably (p<0.05) augmented the gastric mucous secretion on a dose-reliant manner. The study‘s results specify that the EWG has Anti-Ulcer (AU) pharmacologic activity owing to secondary metabolites present within it and encompasses better potential that aids the conventional claims in folklore medicine.

Keywords: Antiulcer effect, peptic ulcer, EWG, ethanol, Omeprazole, ulcer index.


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