Abstract

EVALUATION OF ANTIOXIDANT AND ANTICANCER ACTIVITY OF HOMOCLADIUM PLATYCLADUM

Sunitha Thomas*, Asha Mary John, Gisna Shaji, Krishna R, Gligin Mani and Milu Kuriakose

ABSTRACT

Present study aims to evaluate the invitro Anticancer and Antioxidant activities of aqueous and alcoholic extracts of Homocladium platycladum. Homocladium platicladum, commonly known as centipede plant belongs to the family polygonaceae, is a plant which grows vertically and it is a shrub which covers a large area of land. From the literature survey it has been found that the plant possess wide range of pharmacological activities and it has been used traditionally to treat diseases like diuretic, sedative, hypotensive, antirheumatic. Aqueous and alcoholic extracts were prepared. The preliminary phytochemical analysis revealed the presences of secondary metabolites like flavanoids in aqueous and alcoholic extracts of the plant. Invitro antioxidant activity was screened by standard ABTS method using ascorbic acid as standard. Invitro anticancer activity was investigated by standard MTT assay method using MCF-7 cell lines (Breast cancer cell lines). Both the extracts of H. platycladum possess antioxidant and anticancer activity in a dose dependent manner. Among the extracts alcoholic extract possess more activity. The alcoholic extract shows maximum antioxidant activity at 2000μg and maximum anticancer activity at concentration100 μg.

Keywords: Homocladium platycladum, anticancer, antioxidant, MTT assay, ABTS method.