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Abstract

FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING OFLOXACIN TABLETS USING SEMISYNTHETIC POLYMER

Bijaya Laxmi Giri*, Gyanendra Kumar Raut, Kush Thapa, Omkar Sapkota and Sita Kumari Kohar

ABSTRACT

The main objective of this study was to formulate and evaluate gastroretentive floating Ofloxacin tablets using HPMC K100M. Ofloxacin is an antibiotic useful for the treatment of a number of bacterial infections. Ofloxacin exhibits pH dependent solubility. It is more soluble in acidic pH and slightly soluble in neutral or alkaline pH conditions. The gastroretentive floating tablets of Ofloxacin were prepared to increase the gastric retention, to extend the drug release, and to improve the bioavailability of the drug. The gastroretentive floating tablets were formulated using hydroxy propyl methyl cellulose (HPMC K100M) as a polymer, sodium bicarbonate and citric acid as a gas generating agent by non aqueous granulation technique. The formulated tablets were evaluated for weight variation, hardness, friability, swelling index, floating lag time, and total floating time. The in vitro release study of the tablets was performed in 0.1N HCl as a dissolution media. The formulation F2 showed better sustained drug release and which also had good floating properties. The release profile of this formulation was best explained by first order release kinetics with highest correlation coefficient (R2=0.998) and the drug release was non- fickian diffusion controlled.

Keywords: Ofloxacin, Floating Drug Delivery, Gastroretentive, HPMC K100M.


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