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Abstract

BIOLOGICAL ACTIVITIES OF SELENIUM, VITAMIN-E AND VITAMIN-C AGAINST CADMIUM TOXICITY IN LIVER AND KIDNEY OF MALE ALBINO RAT

Kesavulu V. and Usha Rani A.*

ABSTRACT

Cadmium (Cd) is one of the most toxic heavy metal distributed widely in the environment that deteriorates metabolic activities in the human body. Exposure to Cd occurs by various sources like contaminated food, polluted air, water, beverages, industrial emissions, sewage sludge. The present study was designed to evaluate the toxicity of Cadmium and the protective role of Selenium, Vitamin-E and Vitamin- C on Cadmium induced oxidative stress in the male albino rats. Wistar strain male albino rats were treated with Cadmium Chloride (CdCl2) at a dose of 1/10th LD50/48 hrs that is 22.5 mg/kg /body weight on 7th, 15th, and 30th days of the treatment. On the 15th day card exposed rats were divided into three groups and the 1st group were subjected to Selenium(Se) (1mg/Kg) supplementation, 2ndgroup Vitamin-E(100mg/kg) and Vitamin-C (200 mg/Kg) and 3rd group with the combination of both Se (1mg/Kg), Vit-E (100 mg/Kg) and Vit-C (200 mg/Kg) Supplementation for 7, 15 and 30d experimental period. The rat tissue, liver and kidney were sacrificed after a specific time interval, Cd bioaccumulation and alterations in the oxidative stress enzymes were calculated. The present study supported the possible beneficial effects of supplementation of Se, Vit-E and Vit-C under Cd stress. The present study demonstrates that rather than the individual supplementation of Se, Vit-E and Vit-C tends to detoxify the more Cd induced alterations in the test tissues than the other modes of supplementation.

Keywords: Cadmium; Oxidative stress; Selenium; Vitamin-E; Vitamin- C; Albino Rat.


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