Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2021 Issue has been successfully launched on 1 March 2021.

Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MUCOADHESIVE MICROCPAASULES OF BACLOFEN

Patil Samrudhi Santosh*, Rajdeo Archana Vitthal and Patil Jyoti Narayan

ABSTRACT

Baclofen is muscle relaxant drug used for the treatment of spastic movement disorder, especially in instances of spinal cord injury, multiple sclerosis and also cerebral palsy. Spasm generally result for several hours to minutes. When baclofen is administered orally as a tablet, it is rapidly and completely absorbed and hence increasing the dosing frequency. In the present study an attempt is made to formulate sustained release dosage form of baclofen using chitosan, Carbopol 934P and HPMC K4M as release retarding polymers to reduce dosing frequency and improve patient compliance. Also HPMC and carbopol were used as mucoadhesive polymers. Various batches of microcapsules were developed by varying concentration of chitosan, carbopol and HPMC K4M by using ionic gelation method. Developed mucoadhesive microcapsules were evaluated for various parameters like Bulk density, Tapped density, carr’s index, Hausner’s ratio, Percentage yield, Drug entraptment efficiency, mucoadhesive strength, In-vitro drug release study etc. The formulation F6 found to be optimum based on all evaluation parameters. Also the optimized formulation F6 found to be stable for one month and dosen’t change its colour, shape, release pattern.

Keywords: Chitosan, Carbopol 934P and HPMC K4M, ionic gelation method.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More