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Swapnil M. More* and Sagar S. Kale


Pulmonary drug delivery has attracted tremendous scientific and biomedical interest in recent years and has progressed considerably within the context of local treatment for lung diseases, by virtue of enhanced local targeting and reduced systemic side effects with the administration of minute drug dosages. Furthermore, with the high surface area and permeability of the lung, the 21st century has seen a paradigm shift to inhaled therapy for systemic use. Because of limitations associated with the conventional treatment of various chronic diseases a growing attention has been given to the development of targeted drug delivery systems. Pulmonary route of drug delivery gaining much importance in the present day research field as it enables to target the drug delivery directly to lung both for local and systemic treatment. Pulmonary tract tends to be considered as very promising and attractive route for the administration of active substances intended to treat local pulmonary e.g., asthma, chronic obstructive pulmonary disease (COPD), microbial infections). Among the different respiratory cells, the ciliated epithelial cells of the larger and smaller airways and the type I and type II pneumocytes are the key players in pulmonary drug transport.With their diverse cellular characteristics, each of these cell types displays a unique uptake possibility.Hence, the better understanding of complexes and challenges facing the development of pulmonary drug delivery system offer an opportunity to the pharmaceutical scientist in minimizing the clinical and technical gaps.

Keywords: Dry powder inhaler, lung deposition, pulmonary route, targeted drug delivery, Meter dose inhaler, nebulizer, Fine particle fraction.

[Full Text Article]

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