Abstract

EXCIPIENTS USED IN MANUFACTURING OF TABLETS AND THEIR EFFECT ON PRE AND POST COMPRESSION PARAMETERS-AN OVERVIEW

Autade Yuvraj*, Bhosale Pratiksha, Bhor Surekha, Kale Digvijaysinh and Chavan Krushnabai

ABSTRACT

Pharmaceutical dosage form is a combination of active pharmaceutical ingredients (API) and excipients. Almost all therapeutic products include excipients. The excipients are pharmacologically inactive substances used in tablet manufacturing to improve dissolution rate and bioavailability of drug. Additives are used to maintain physiochemical stability and to improve functioning of dosage form. Excipients provide bulk to the dosage forms and also facilitates drug absorption and solubility. Excipients play key role in pharmacokinetic behavior of the formulation. The selection of appropriate excipients depends upon the route of administration and dosage form, as well as the active ingredient and other factors. The common types of tablet excipients such as binders, lubricants, coating agents, glidants, antiadherants, disintegrants, flavors, colorants etc. are described in the present review. This paper deals with the various aspects of commonly used excipients for the manufacturing of tablets. Excipients which are used for different types of tablets for site specific delivery have been discussed in this review. Excipients which controls delivery of active pharmaceutical ingredients for specific duration are also been discussed. Excipients used in direct compressible tablets are given in this review article. This review will help the researchers and academicians in the selection of excipients for solid oral dosage forms such as tablets.

Keywords: Excipients, Compression, Disintegrants, Glidants, Bioavailability.