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Abstract

FORMULATION AND EVALUATION OF ARIPIPRAZOLE ORAL DISINTIGRATING TABLET

Shikha Kuksal*

ABSTRACT

Aripiprazole is an atypical antipsychotic agent used for treatment of schizophrenia, bipolar disorder and major depressive disorders. The efficacy of aripiprazole is mediated through a combination of partial agonist activity at dopamine D2 and serotonin 5HT-1A receptors and antagonist activity at 5HT-2A receptors. Thus, the main objective of the study is to formulate taste masked oral disintegrating tablet of aripiprazole by using inclusion complex beta-cyclodextrin to achieve a better dissolution rate and further improving the bioavialability of the drug. The prepared batches of tablets were evaluated for hardness, weight variation, thickness, friability, drug content, disintegration time, wetting time, in vitro dispersion time, and in vitro dissolution profile. Among all, the formulation f15 containing crospovidone 5% was considered to be the optimum formulation, which released nearly 99% of the drug in 20 minutes with a disintegration time of 10. 20 seconds. These studies indicate the viability and benefits of oral disintegrating tablets of aripiprazole. Oral disintegrating tablets were prepared by direct compression method using super disintegrant like crospovidone, croscamellose sodium, sodium starch glycolate and combination of crospovidone with croscarmellose sodium, and crospovidone with sodium starch glycolate in different concentrations. They were evaluated for the pre-compression parameters such as bulk density, compressibility, hausner ratio and angle of repose.

Keywords: .


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