Abstract

IRISIN AND ITS EFFECTS ON CARDIOMETABOLIC DISEASES IN PHYSICAL CONDITIONING AND TREATMENT OF COVID-19

Raphael Benassi, Debora de Oliveira da Silva, Eduarda Romeu da Silva Nogueira, Emanuelle Pires da Silva, Jessyca Damazio de Oliveira, Thiago da Silva Manhaes, Eva de Fátima Rodrigues Paulino, Anibal Monteiro de Magalhães Neto and Luis Carlos Oliveira Gonçalves*

ABSTRACT

The main objective of the present study was to carry out an unsystematic and narrative review of the literature on the hormone Irisin, showing its relevance to cardiovascular diseases and to COVID-19, highlighting how its synthesis is induce by physical exercise. Irisin was describe first in 2012, being an important hormone secreted by muscle cells, and is related to the transformation of white adipose tissue into brown adipose tissue, potentiating thermogenesis. This hormone has therapeutic aspects and was relevant in the treatment of some diseases, such as type 2 diabetes and cardiovascular diseases. One of the most important aspects is that the release of this hormone is stimulated through vigorous physical exercises, which points to this practice as beneficial to health. Currently, this hormone has shown positive evidence regarding the treatment of COVID-19, reducing the expression of the protein genes that the virus binds and making it difficult for SARS-CoV-2 to enter human cells.

Keywords: Irisin, COVID-19, SARS-CoV-2.