Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS JANUARY ISSUE PUBLISHED
  • JANUARY 2021 Issue has been successfully launched on 1 January 2021.

Abstract

METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION OF TIMOLOL MALEATE AND TRAVOPROST IN BULK AND IN PHARMACEUTICAL DOSAGE FORM BY UV-SPECTROSCOPY AND RP-HPLC

Jothieswari Dhamotharan*, Kovai Venkata Sai Heera, Amasa Pavan Kumar, Katta Govardhan, Kadiyala Himaja, Siva Kumar Vidya Sagar and Bala Venkata Ramana Chandana

ABSTRACT

The blend of these two medications (Timolol maleate and Travoprost) is utilized to bring down the weight in the eye when one of the drugs doesn't bring down the weight enough all alone. The eye drops should be layed into the influenced eye(s) once every day. The point of the current examination is to grow new scientific strategies for the synchronous assessment of Timolol maleate and Travoprost in mass and in Pharmaceutical dose structure. Spectroscopic strategies have been produced for the evaluation of Timolol maleate and Travoprost in mass and in the plan. A straightforward, fast and exact RP-HPLC strategy for synchronous quantitative assurance of Travoprost and Timolol maleate in ophthalmic arrangement was created. Chromatographic partition was accomplished with PDA finder utilizing PHENOMENOX C18, 15O×4.6 mm; 5 micron turn around stage logical segment. The portable stage comprise of ortho phosphoric corrosive (0.1%): methanol (60: 40 v/v), was gone through the segment at stream pace of 0.8 ml/min. The strategy was performed at the frequency 272nm by isocratic procedure. The investigation was done at 25oC. The maintenance season of Travoprost and timolol maleate was discovered to be 6.322 min and 3.730 min. The alignment bends were direct in the focus scope of half to 150% of the working fixation (r2> 0.999). The lower furthest reaches of evaluation were 0.142 and 0.0069 for Timolol maleate and Travoprost individually. The lower furthest reaches of location were 0.043 and 0.0021 for Timolol maleate and Travoprost respectively. The created strategy was utilized for synchronous quantitative assessment of Travoprost and Timolol maleate in ophthalmic arrangement. Created technique was approved according to ICH Q2 (R1), and it is generally valuable for scholastic just as mechanical scale.

Keywords: Timolol maleate, Travoprost, Double distilled water, RP-HPLC method.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More