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Abstract

METHOD DEVELOPMENT AND VALIDATION OF PREGABALIN AND ETORICOXIB IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV SPECTROSCOPY (STANDARD ADDITION) METHOD

Prakash M., Abirami G.* and Vetrichelvan T.

ABSTRACT

A simple, rapid and specific UV spectroscopic method with good sensitivity was developed and validated for the simultaneous determination of Pregabalin and Etoricoxib in bulk and pharmaceutical dosage form by standard addition method. In 0.1N HCl the λmax of Pregabalin and Etoricoxib was fixed as 212 nm and 234 nm respectively using a Labindia UV (3000+) Visible spectrophotometer. In this proposed method Pregabalin less sensitivity when compare to Etoricoxib The drugs obeyed linearity within the concentration range of 100-500 μg/ml and 3-15 μg/ml for Pregabalin and Etoricoxib respectively. The low RSD values indicate good precision and high recovery values indicate accuracy of the proposed method. The proposed method has been applied to the determination of drugs in commercial formulations. Assay results were in good agreement with label claim was found to be 100.19% and 99.53% of Pregabalin and Etoricoxib. The method was validated as per ICH guidelines. The developed method was simple, accurate, precise, specific, sensitive and reproducible which can be efficiently and easily applied to pharmaceutical dosage forms.

Keywords: Pregabalin, Etoricoxib, UV-Visible spectrophotometer, Simultaneous determination by Standard addition method.


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