Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2020 Issue has been successfully launched on 1 November 2020

Abstract

STUDY OF LPRM GENE IN IRAQI MYCOBACTERIUM TUBERCULOSIS ISOLATES

Asraa A. Abdul-Jalil , Zahra M. Al-Khafaji* , Ahmed A. Mankhi, Ruqaya M. Ali ,Mohammed Q. Al-Ani

ABSTRACT

Tuberculosis (TB) represents one of the most threatening disease in human beings . It caused mainly by Mycobacterium tuberculosis , which gets a lot of virulence factors . The aim of this study was to investigate and study the LprM gene , which accused in internalization of M. tuberculosis in human macrophages . For the Iraqi patients suffering from pulmonary TB tow methods were used to extract the DNA (using CTAB and Triton-X) . The gene amplified with LprM RD7 primers , the resulted PCR product 1116 bp were sequenced for tow typical M. tuberculosis (at phenotypic characterization) (Asraa25R and Asraa28R , were deposited in NCBI with Accession numbers KJ809110 , KJ809111 respectively ) . Resulted sequences and their translated protein sequences were investigated thoroughly using different Bioinformatics tools . Results revealed that 70% of infections in Iraqi patients with pulmonary TB are due to typical M. tuberculosis , which differ from M. tuberculosis complex . The phylogenic estimation put the resulted sequences in mycobacterial group.

Keywords: LprM gene . TB in Iraq , M. tuberculosis , spoligotyping , Rv1970 (RD7) , phylogeny , NCBI Acc. No. KJ809110 , KJ809111


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More