Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL FLAVONES DERIVATIVES AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS

N. Ramalakshmi*, P. Manimegalai, S. R. Chitra and S. Arunkumar

ABSTRACT

Infectious diseases are caused due to microorganisms like virus, bacteria, fungi or parasite. Infectious diseases are a leading cause of death worldwide, especially in young children. As per national centre for health statistics, about 16.8 million people visit physician for infectious and parasitic infections. Though antibiotics are successful in the treatment of microbial infections, they may cause superinfections, preceded by colonization with resistant micro-organisms. This shows the need for new lead molecules against microbial infections with minimal side effects. A series of copper, nickel and cobalt metal complexes of flavones were synthesized and the structures were confirmed by their IR and 1H NMR. They were tested for antimicrobial activity by paper disc diffusion method, MIC agar streak dilution method. They were also tested for antioxidant activity by nitric oxide radical scavenging method. Among the synthesized compounds 1,3,5,6 and 8 showed good antimicrobial activity with an MIC 11.1-1.1μg/mL and antioxidant activity with IC50 17.9-26.4μg/mL. Among these compounds2-(3-hydroxyphenyl)-3-[{{2-{3-hydroxyphenyl}-4-oxo-4Hchromon-3-yl]oxy}nickeltio}oxy]-4-H-chromen-4-one 8 has shown excellent antimicrobial activity in MIC determination by agar streak dilution method and antioxidant activity by Nitric Oxide radical scavenging method. In conclusion, we synthesized molecules with potent and selective antimicrobial activity and antioxidant activity.

Keywords: Flavones, Copper, Nickel, Cobalt, antimicrobial, antioxidant.