WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

FORMULATION AND EVALUATION OF MOXIFLOXACIN HYDROCHLORIDE OCULAR INSERTS

Daisy Chella Kumari S.* and Manimegalai V.

ABSTRACT

Objective: The polymeric system have been used to fabricate ocular inserts for improve ocular bioavailability and retention of drug in the system have shown advantages of reduce dosing frequency and increased corneal residence time. The objective of the present study was to formulate and evaluate ocular inserts of Moxifloxacin hydrochloride. Methods: Ocular inserts are made from an aqueous dispersion of Moxifloxacin hydrochloride, Hydroxy propyl methyl cellulose K4M, Poly vinyl alcohol, Poly vinyl pyrrolidinr K30by solvent casting method. The ocular inserts (oval shape of length of 1.4cm and width of 0.5 cm) were characterized for thickness, uniformity of weight, Drug contemnt uniformity and surface Ph. Results: The thickness and drug content of ocular insert were found in the range of mg respectively. The ocular insert formulated by using HPMC and PVA shows the maximum drug release i.e. at 12h. The stability studies suggest that all the ocular insert remained stable, showed lesser degradation rate and maximum shelf life. Conclusion: ocular inserts of Moxifloxacin hydrochloride prepared successfully by using solvent casting method for sustained drug delivery.

Keywords: Moxifloxacin hydrochloride, Ocular insert, Polyvinyl alcohol, Hydroxy propyl methyl cellulose, Polyvinyl pyrrolidine.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More