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Abstract

FORMULATION AND EVALUATION OF MOXIFLOXACIN HYDROCHLORIDE OCULAR INSERTS

Daisy Chella Kumari S.* and Manimegalai V.

ABSTRACT

Objective: The polymeric system have been used to fabricate ocular inserts for improve ocular bioavailability and retention of drug in the system have shown advantages of reduce dosing frequency and increased corneal residence time. The objective of the present study was to formulate and evaluate ocular inserts of Moxifloxacin hydrochloride. Methods: Ocular inserts are made from an aqueous dispersion of Moxifloxacin hydrochloride, Hydroxy propyl methyl cellulose K4M, Poly vinyl alcohol, Poly vinyl pyrrolidinr K30by solvent casting method. The ocular inserts (oval shape of length of 1.4cm and width of 0.5 cm) were characterized for thickness, uniformity of weight, Drug contemnt uniformity and surface Ph. Results: The thickness and drug content of ocular insert were found in the range of mg respectively. The ocular insert formulated by using HPMC and PVA shows the maximum drug release i.e. at 12h. The stability studies suggest that all the ocular insert remained stable, showed lesser degradation rate and maximum shelf life. Conclusion: ocular inserts of Moxifloxacin hydrochloride prepared successfully by using solvent casting method for sustained drug delivery.

Keywords: Moxifloxacin hydrochloride, Ocular insert, Polyvinyl alcohol, Hydroxy propyl methyl cellulose, Polyvinyl pyrrolidine.


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