Abstract

COUNTERACTION AND TREATMENT OF HYPERTENSION AND HEART FAILURE BY TARGETING RAAS AND NATRIURETIC PEPTIDES

Sachin*, Mahima Saini and Shivank Awasthi

ABSTRACT

Heart failure and hypertension are the two developing conditions and have been on a way to turn into the most widely recognized conditions in the world since the time they began which is undeniable from the day by day increment in the number of patients around the globe. They can be caused due to any different number of factors like some diseases or conditions which often lead to these or else directly and most importantly due to disturbance in enzymes systems like RAAS or NPS which are 2 most important systems in human body among many and consists of enzymes like renin, angiotensin I, angiotensin II and various other forms of it; which plays a very crucial role in the regulation of various cardiovascular functions and renal functions also. In this way, if there is an aggravation in any of the frameworks or the chemicals in question and the chain of cycles gets upset which brings about such conditions and can likewise be controlled or treated by controlling the factor that is causing the difficulty that is if renin is expanding, at that point a renin inhibitor can be utilized or for other such reasons ACE inhibitors, mineralocorticoid receptor foes, and ARBs can be utilized. These days, an alternate catalyst that is neprilysin is likewise being viewed as a target that can have useful impacts if repressed subsequently the angiotensin – neprilysin inhibitors are created to treat the issue more compellingly. Thus, we have the issue however we likewise have the arrangement yet numerous individuals don't have the assets to get to the data concerning that assets. Because of which we have attempted to make an asset in this structure that incorporates data about issues, factors included, and the arrangements as medications.

Keywords: Heart failure, RAAS, NP’s, Hypertension.