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Abstract

SPECTROPHOTOMETRIC MICRO DETERMINATION OF MECLIZINE HYDROCHLORIDE IN THEIR PHARMACEUTICAL FORMULATIONS AND SPIKED PLASMA

Hamid M. Younis and Hany A. Omara*

ABSTRACT

proposed for the rapid determination of meclizine hydrochloride using bromocressol green (BCG) and bromophenol blue (BPB). The method consists of extracting the formed ion- associates into chloroform. The ion -associates exhibit absorption maxima at 417 and 412 nm for BCG and BPB, respectively. Meclizine HCl can be determined up to 2.6-25 and 2.5-17.5 μg/ml, using BCG and BPB, respectively. The effect of acidity, reagent concentration, time, solvent and stoichiometric ratio of the ion- associates were studied. The molar absorptivity and Sandell sensitivity of the reaction products were calculated. The method was applied to the determination of the drugs in their pure form or pharmaceutical preparations.

Keywords: Meclizine hydrochloride; Spectrophotometric; bromocressol green (BCG) and bromophenol blue (BPB); Pharmaceutical analysis.


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