Abstract

ROLE OF RED BEETROOT (BETA VULGARIS) JUICE ON CHRONIC NANOTOXICITY OF SILVER NANOPARTICLES (AGNPS) INDUCED HEMATOTOXICITY IN RATS

Tarfa Albrahim,*, Mona A. Alonazi, Ahmed M. Y. Alobeidli and Alwin Robert

ABSTRACT

The present study aimed to investigate the protective effects of Beta vulgaris root juice (RBR) in a male rat intoxicated with silver nanoparticles (AgNPs)-induced hematological toxicity model. Hematological parameters and oxidative stress markers were assessed. RBR protected against AgNPs-induced hematological toxicity evidenced by preventing RBCs and Hb% reduction and WBCs and platelet count increment. Furthermore, RBR restrained oxidative stress by preventing lipid peroxidation, and nitric oxide formations, and glutathione depletion. The obtained data demonstrated that post-treatment with RBR attenuated AgNPs-induced hematological toxicity by attenuated hematological parameters disturbance and oxidative stress induction in rats.

Keywords: Beta vulgaris; silver nanoparticles; hematological parameters; oxidative stress.