Abstract

FORMULATION AND EVALUATION OF MOXIFLOXACIN MICROBEADS FOR ORAL DRUG DELIVERY SYSTEM

Namrata Shahi, Sourabh Jain* and Karunakar Shukla

ABSTRACT

The present study aimed at designing and evaluating microbeads for localized controlled release of drug to achieve a minimum inhibitory concentration in the oral drug delivery system. The microbeads were prepared by ionotropic gelation technique. Four types of microbeads were prepared by using sodium alginate alone and combination with other polymers like HPMC, chitosan, pectin and calcium chloride used as counter ion. The formulations were characterized by particle size, Scanning electron microscopy (SEM), swelling index (3.32%), drug entrapment efficiency (80.25%) and drug release (90.32%) in 6.8 phosphate buffer. The results indicated that the formulation of sodium alginate Moxifloxacin pectin microbeads could be utilized to maintain the localized drug concentration for a longer period and increase patient compliance with lesser adverse effects.

Keywords: Microbeads; HPMC; Sodium alginate; Moxifloxacin; SEM.