WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF METAL COMPLEXES DERIVED FROM 3-METHYL-NHYDROXYBENZAMIDINE AS POTENT INHIBITORS OF THYMIDYLATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS

Hitendra Kumar Lautre*, Royana Singh, Kishore Patil, Taibi Ben Hadda, HafidYoussouffi, Prasenjit Bose, Mayank Krishna Kulshrestha, Chandreshwar PrasadSinha, Ajai Kumar Pillai, Snigdha Das

ABSTRACT

Present work investigate the synthesis of Co(II), Cr(II) and Zn(II) complexes of 3-methyl-N-hydroxybenzamidine as potent and selective inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMK). Structural properties were confirmed by NMR, IR, UV-vis, Mass spectral, elemental data and thermogravimetric analysis. The inhibitory concentration at 50% (IC50) and inhibition constant Ki of each compound were measured against the thymidylate kinase. The IC50 of all the compounds ranges 37-86 μM, Ki obtained was 54-195 μM against MtTMK. Antibacterial activity of all the compounds exhibited high selectivity and potency against the selected bacterial strains, compared of ampicillin, which was confirmed by the MIC values. DNA cleavage and antioxidant activities exhibited that all compounds have multi target properties. Antioxidant activities of ligand was higher compared to metal complexes.

Keywords: Thymidylate kinase inhibitor, tuberculosis, amidine metal complexes, M.tuberculosis.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More