Abstract

SERUM ALKALINE PHOSPHATASE LEVEL IN NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS

Ruaa Nazar AL-Saraj* and Afraa Mohammed AL- Ameen

ABSTRACT

Background: Type 2 diabetes mellitus is a major health problem in the world. It has been found that many diabetics may have high serum alkaline phosphatase level which is a hydrolytic enzyme acting at pH 10 that present in several isoenzyme mainly as bone and liver isoenzymes. The Aim of the Study: To assess the serum alkaline phosphatase level in type 2 diabetes mellitus. Methods: A prospective case control study was conducted at Al- Wafaa center of diabetic management in Mosul, northern Iraq from October 2019 to April 2020. 77 newly diagnosed type 2 diabetic patients from both genders aged (35-65) ± 5 as case group and 84 matched age and gender apparently healthy subjects as control group and the following tests were done (fasting plasma glucose and serum alkaline phosphatase). Results: Diabetic patients have significant high family history of diabetes than controls (p= 0.03). ALP level was significantly higher in diabetics than control group (p= 0.01). In this study, there was no significant association between ALP level and fasting blood glucose. Conclusion: The outcomes of the present study suggest that Alkaline Phosphatase (ALP) have shown higher activity with T2DM patients than non diabetic subjects.

Keywords: Type 2 diabetes mellitus, Alkaline phosphatase, Fasting Blood glucose, ALP, Newly diagnosed.