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Khushbu G. Rahangdale*, Nitin H. Indurwade, Sarita Chauragade, Saumya G. Katre, Amit K. Goplani, Shraddha B. Shelke, Bhumesh P. Lilhare, Suchita P. Patle and Avinash D. Gangwani


The aim of the present study was to evaluate the antimicrobial activities of aqueous extract of leaf of Argemonemexicanaand root of Alangiumsalvifolium. The aqueous leaf extracts of Argemonemexicanawere subjected to qualitative tests, by screening of phytoconstituents that present in the extracts, and to quantitative tests by evaluation of antimicrobial activity using well agar diffusion method. The aqueous root extract of Alangiumsalvifoliumwas prepared and were tested on Gram positive bacteria. Agar cup plate test was used to determine the sensitivity of the tested samples while the well microdilution was used to determine the minimum inhibitory concentration. The drug extract were extracted using solvent extraction by soxhlet apparatus, different concentration of these extract were prepared ranging 0.1-1.0mg/ml and antimicrobial activity is performed on Staphylococcus aureus (gram positive) bacteria using nutrient agar medium as broth. It was found that the above drug combination (Argemonemexicana, Alangiumsalvifolium) on the respective gram positive bacteria (Staphylococcus aureus) was showing significant antimicrobial activity. The minimum inhibitory concentration of combination of both drugs was found to be 6.1mm for the concentration of 4:6 mg/ml for both drugs. The overall results of this study indicates that the extract from both the drugs have interesting antimicrobial and potential free radical scavenging activity for treatment of psoriasis disease.

Keywords: Alangiumsalvifolium (L.F.) wang, Argemonemexicana L., MIC: Minimum inhibitory concentration, Streptococcus aureus, psoriasis disease.

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