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Jaydeep Chauhan*, Dr. Jigar Vyas and Dr. Um Uphadyay


Greying of hair is an inevitable phenomenon that occurs commonly as a person ages. It usually occurs in the fourth decade regardless of gender but now a day, even people in their early twenties can experience premature greying.[1] Hair graying is a common sign of aging resulting from complex regulation of melanogenesis. There is also low-quality evidence that some vitamin B complex supplementation can promote gray hair darkening. While these compounds are not currently indicated for the treatment of gray hair, their mechanisms shed light on targets for future medications for hair re-pigmentation. Currently, there is no medical treatment available for hair re-pigmentation. In this article we review the literature on medication-induced hair re-pigmentation, discuss the potential mechanisms of action, and review the quality of the literary data. Diffuse Regimentation of gray hair can be induced by certain medications that inhibit inflammation or stimulate melanogenesis.[2] Adipose derived autologous mesenchymal stem cells have been transplanted and tested for their ability to regenerate tissues for several indications. In this article it is intend to report this unique observation which may lead to further research and solutions to problems like premature greying of hair or indicate new antiaging solutions.[3] Intricate coordinated mechanisms that govern the synchrony of hair growth and melanin synthesis remain largely unclear. These two events can be uncoupled in prematurely gray hair, probably due to oxidative insults that lead to the death of oxidative stress-sensitive melanocytes. This article provides the first clear evidence that compromised antioxidant activity in gray hair follicles simultaneously affects mature hair bulb melanocytes and their immature precursor cells in the bulge region.[4] Premature Greying is the term used when hair turn grey prematurely. Though greying of hair is a natural process, yet in the modern era of cosmetologically revolution, it has assumed a lot of aesthetic relevance, especially premature hair greying. There are various known causes of premature hair greying like Excessive prolonged stress, Thyroid Deficiencies, Excessive intake of tea, coffee and alcohol, fried foods, spices, sour and acidic foods, Deficiency of nutrients esp. copper reduces melanin production, Deficiency of B 12& Biotin and hereditary causes.[5]

Keywords: Mesenchymal stem cells, human hair, melanocyte, melanin.

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