Abstract

ANTINOCICEPTIVE AND ANTI -INFLAMMANTORY STUDY OF METHANOLIC EXTRACT OF ANNONA SQUAMOSA LEAVES ON MICE

Achla Vyas*, Rajendra Bapana, Kapil Vyas and Rajesh Kumar Nema

ABSTRACT

Annona squamosa, a plant famous for the sweetness of its fruits, earlier research shows, bark, leaves, seeds, of this plant have many medicinal properties like analgesics, anti-inflammatory, antioxidant, antibacterial, antifungal, antiulcer, anticancer, antidiabetic. Soreness produces discomfort, pain & inflammation is the most common sign of any sickness or grievances. On the basis of pain, we diagnose a number of diseases that are very uncomfortable for the patient. To overcome this situation we used pain killers or antinociceptive drugs that are also known as an analgesic and anti-inflammatory that are the molecules that produce relief from pain & inflammation. Nowadays there are so many types of the NSAIDs present in the market but the aim of the study is to reboot the traditional system of medication because the organic molecules create dependence for our body & for this, our body easily creates tolerance for the particular drug. In our study, we used plant Annona squamosa to determine its antinociceptive and anti-inflammatory properties. The activity involves, selection of plant, collection of leaves, methanolic extract, phytochemical & pharmacological study. Tail flick, Eddy’s hot plate, Acid-induced writhing test method is used for the examination of antinociceptive & anti-inflammatory activity in mice.

Keywords: Annona squamosa, antinociceptive, anti-inflammatory, tail-flick method, hot plate method.