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Noor Hasan*


The aim of this study was to prepare and characterize beads of Gelucire Preparation of formulation by varying various Gelucire 43/01, 48/16, 50/13 like amount of lipid, amount of drug.43/01 for floating delivery of Nebivolol hydrochloride (NH) is antihypertensive drug having β-adrenergic blocking properties. Although NEB is rapidly absorbed after oral administration, it has low bioavailability (12%), due to its poor solubility in water. The purpose of present work was to enhance improve bioavailability or solubility and The beads were evaluated for particle size, surface morphology, percent drug entrapment, percent yield,, FTIR spectrum of Nebivolol HCl in vitro floating ability, and in vitro drug release.scanning electron microscopy, and in vitro floating ability. The formed beads were sufficiently hard and spherical in shape. Photomicrographs show that the surface was porous in nature. The average particle diameter of beads was found to be in the size range of 2.0 to 2.86 mm, and percent entrapment was 49.388% to 68.684%. The beads demonstrated favorable in vitro floating ability. Prepared formulations showed better controlled release behavior when compared with its conventional dosage form and comparable release profile with marketed sustained release product. HSM photomicrograph showed presence of some unmelted portion even at 43°C and completely melts on 51°C in aged sample. It was found that there was no significant effect on floating ability of aged beads since it remains floats up to 8 h study period. Thus, it is concluded that beads of Gelucire 43/01 could be serve as an effective carrier for highly water-soluble antihypertensive drugs like NH for the controlled delivery.

Keywords: floating drug delivery; beads; Gelucire 43/01; Nebivolol HCl; Dripping Technique.

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