Abstract

OPHTHALMIC FORMULATION AND EVALUATION OF OFLOXACIN IN- SITU GEL

Dr. Deepika Joshi, Dr. Praveen Kumar and Sakshi Nainwal*

ABSTRACT

In situ gels are drug delivery systems which are in solution form before administration in the body, but once administered, undergo gelation, to form a gel depending upon external factors such as temperature, pH etc present in environment. The present work is to formulate and evaluate Ofloxacin eye gel which is used in treatment of conjunctivitis. It is an antibiotic which belong to the group of medications called fluoroquinolones that are used to treat bacterial infections. Sodium alginate, an ophthalmic gel forming gelling agent was chosen which undergoes gel formulation. Hydroxy Propyl Methyl Cellulose(HPMC K4 M)was used as a viscosity enhancer in order to achieve the desired consistency. The Preliminary evaluations like visual appearance, pH of gel drug content, rheological studies, spreadability and extrudability.

Keywords: Ofloxacin, in- vitro drug release, in-situ gel, enhance HPMC.